Dexin Kong Selected Research

Neoplasms (Cancer)

1/2024	A novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation.
12/2023	Activation of the EGFR/PI3K/AKT pathway limits the efficacy of trametinib treatment in head and neck cancer.
10/2023	Development of PI3Kα inhibitors for tumor therapy.
8/2023	Discovery of a Novel Ubenimex Derivative as a First-in-Class Dual CD13/Proteasome Inhibitor for the Treatment of Cancer.
1/2023	Stellettin B Sensitizes Glioblastoma to DNA-Damaging Treatments by Suppressing PI3K-Mediated Homologous Recombination Repair.
1/2023	Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC.
1/2023	Mutated HRAS Activates YAP1-AXL Signaling to Drive Metastasis of Head and Neck Cancer.
12/2022	NIR-II Fluorescence Imaging-Guided Oxygen Self-Sufficient Nano-Platform for Precise Enhanced Photodynamic Therapy.
11/2022	Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1.
9/2022	Discovery of Novel PI3Kδ Inhibitors Based on the p110δ Crystal Structure.

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Dexin Kong Research Topics

Disease

49	Neoplasms (Cancer) 01/2024 - 10/2007
10	Neoplasm Metastasis (Metastasis) 01/2023 - 01/2011
10	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/2022 - 04/2004
9	Leukemia 11/2022 - 01/2008
7	Carcinogenesis 10/2023 - 06/2010
5	Glioblastoma (Glioblastoma Multiforme) 01/2023 - 07/2014
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 01/2016
5	Prostatic Neoplasms (Prostate Cancer) 12/2021 - 06/2013
5	Inflammation (Inflammations) 01/2021 - 10/2007
3	Head and Neck Neoplasms (Head and Neck Cancer) 12/2023 - 05/2021
3	Breast Neoplasms (Breast Cancer) 10/2023 - 04/2016
3	Infections 01/2018 - 12/2013
3	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 01/2016
3	Type 2 Diabetes Mellitus (MODY) 01/2018 - 12/2015
2	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 11/2023
2	Hypoxia (Hypoxemia) 09/2023 - 01/2019
2	Human Influenza (Influenza) 08/2023 - 01/2022
2	Lung Neoplasms (Lung Cancer) 01/2023 - 01/2022
2	Heart Failure 10/2021 - 01/2020
2	Tetraploidy 01/2020 - 03/2017
2	Hypersensitivity (Allergy) 06/2019 - 12/2018
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2018 - 06/2017
2	Body Weight (Weight, Body) 01/2018 - 01/2017
2	Asthma (Bronchial Asthma) 08/2017 - 01/2009
1	Iron Deficiencies 05/2024
1	Squamous Cell Carcinoma of Head and Neck 12/2023
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 09/2023
1	Multiple Myeloma 08/2023
1	Influenza in Birds (Avian Flu) 08/2023
1	Colorectal Neoplasms (Colorectal Cancer) 05/2023

Drug/Important Bio-Agent (IBA)

9	ZSTK474IBA 01/2022 - 10/2007
8	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2018 - 09/2008
6	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 01/2016
5	stellettin BIBA 01/2023 - 07/2014
5	Protein Isoforms (Isoforms)IBA 05/2021 - 10/2007
5	SesquiterpenesIBA 12/2017 - 04/2004
4	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 09/2023 - 01/2018
4	Proteins (Proteins, Gene)FDA Link 09/2023 - 12/2019
4	idelalisibIBA 09/2022 - 12/2016
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2024 - 01/2017
3	Mitogen-Activated Protein KinasesIBA 12/2023 - 01/2018
3	TriterpenesIBA 01/2021 - 07/2014
3	Immunoglobulin E (IgE)IBA 06/2019 - 08/2017
3	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2018 - 12/2015
3	smenospongineIBA 01/2011 - 04/2004
2	trametinibIBA 12/2023 - 01/2022
2	AlpelisibIBA 12/2023 - 10/2023
2	Proteasome InhibitorsIBA 08/2023 - 01/2021
2	VaccinesIBA 08/2023 - 01/2022
2	hirsuteineIBA 05/2023 - 11/2022
2	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 01/2020
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2023 - 01/2021
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2023 - 09/2008
2	Hormones (Hormone)IBA 01/2023 - 06/2013
2	Adenosine Triphosphate (ATP)IBA 01/2023 - 01/2019
2	Gefitinib (Iressa)FDA Link 01/2022 - 01/2021
2	AntigensIBA 01/2022 - 06/2019
2	NVP-BKM120IBA 11/2021 - 01/2021
2	Digoxin (Digitek)FDA LinkGeneric 10/2021 - 01/2020
2	Insulin (Novolin)FDA Link 05/2021 - 01/2018
2	matrigelIBA 01/2021 - 01/2021
2	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2018
2	luteolin-7-glucosideIBA 01/2020 - 03/2017
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 07/2018
2	Chlorogenic AcidIBA 01/2020 - 03/2017
2	IntegrinsIBA 12/2019 - 08/2018
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2019 - 01/2018
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019 - 03/2009
2	Peptides (Polypeptides)IBA 01/2018 - 01/2018
2	O-diacetylbritannilactone OIBA 12/2017 - 08/2017
2	Phosphotransferases (Kinase)IBA 01/2017 - 06/2010
2	TOR Serine-Threonine KinasesIBA 01/2017 - 01/2016
2	Class I Phosphatidylinositol 3-KinasesIBA 01/2017 - 04/2016
2	bcr-abl Fusion ProteinsIBA 12/2016 - 01/2016
2	aaptamineIBA 01/2011 - 03/2006
2	AlkaloidsIBA 03/2006 - 07/2004
1	Basic Helix-Loop-Helix Transcription FactorsIBA 05/2024
1	SaltsIBA 05/2024
1	Amyloid (Amyloid Fibrils)IBA 12/2023
1	ErbB Receptors (EGF Receptor)IBA 12/2023
1	Neurotransmitter Agents (Neurotransmitter)IBA 11/2023
1	ButyrylcholinesteraseIBA 11/2023
1	Acetylcholine (Acetylcholine Chloride)FDA Link 11/2023
1	Hypochlorous Acid (Hypochlorite)IBA 11/2023
1	sapanisertibIBA 09/2023
1	CollagenIBA 09/2023
1	Bleomycin (Blenoxane)FDA LinkGeneric 09/2023
1	indium-bleomycinIBA 09/2023
1	ubenimexIBA 08/2023
1	ixazomibIBA 08/2023
1	Hemagglutinins (Hemagglutinin)IBA 08/2023
1	Subunit VaccinesIBA 08/2023
1	Inactivated VaccinesIBA 08/2023
1	Indole AlkaloidsIBA 05/2023
1	Sincalide FDA Link 01/2023

Therapy/Procedure

28	Therapeutics 01/2024 - 09/2008
4	Drug Therapy (Chemotherapy) 08/2023 - 01/2010
2	Oral Administration 01/2019 - 11/2018
1	Photochemotherapy (Photodynamic Therapy) 12/2023